Synvisc, Hyalgan, Orthovisc viscosupplementation for osteoarthritis

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Approved by the U.S. Food and Drug Administration, ORTHOVISC is now available to patients through physicians’ offices. It is an injectable form of ultra-pure hyaluronic acid that can be given in a series of three weekly injections into the knee joint. The hyaluronan used in ORTHOVISC is similar to healthy human synovial fluid, a substance that lubricates the knee joint.

Genzyme Biosurgery (Nasdaq: GZBX), a division of Genzyme Corp., announced today that it has gained approval in the European Union to market Synvisc(R) (Hylan G-F 20) for the treatment of osteoarthritis pain in the hip.

AAOS: Patients Prefer Hylan G-F 20 Over Intra-Articular Steroids for Knee Osteoarthritis
By Jill Stein
SAN FRANCISCO, CA -- March 12, 2004 -- Patients with osteoarthritis of the knee who are treated with Synvisc (Hylan G-F 20) are
more satisfied with their therapy than patients treated with intra-articular steroids, researchers reported on March 11th here at the 2004 Annual Meeting of the American Academy of Orthopedic Surgeons.

The clinical trial was a single-center study of 56 women and 52 men with an average age of 62 years old. Trial participants had osteoarthritis in one or both knees and had failed treatment with NSAIDS or cortisone injections. During the trial the participants received three intra-articular injections of Synvisc given one-week apart. Patient assessments were done at 1, 3, 6, 12, 15, and 18 months.

The Hospital For Special Knee Surgery Rating Scale was used to evaluate the pain relief and ability to avoid total knee replacement surgery. Results indicated that 72.6 percent of patients treated with Synvisc avoided the total knee replacement surgery throughout the study.

(Mar. 30) -- Osteoarthritis of the knee is a painful condition that often leads to a surgical solution. But Eyewitness News spoke with a local surgeon who says many people may be candidates for an alternative.
A person with osteoarthritis loses cushioning in their knee, causing the bones to rub together. The result is some serious pain. If the usual anti-inflammatory medications are ineffective -- and the patient would prefer to delay having knee surgery -- there may be an alternative.
Las Vegas orthopedic surgeon, Edward Ashman (Nevada Orthopedic & Spine Center), can often help the patient with injections of a lubricating substance known hyaluronic acid

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