Synvisc, Hyalgan, Orthovisc viscosupplementation injections
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ORTHOVISC is a sterile, non-pyrogenic solution of sodium hyaluronate.

Sodium hyaluronate is a high molecular weight polysaccharide composed of sodium glucuronate and N-acetylglucosamine. Sodium hyaluronate is ubiquitously distributed throughout the tissues of the body and is present in high concentrations in such tissues as vitreous humor, synovial fluid, umbilical cord and dermis. Sodium hyaluronate functions as a tissue lubricant and is thought to play an important role in modulating the physical and mechanical interactions between adjacent tissues. It can also act as a visco-elastic support maintaining a separation between tissues.  ORTHOVISC is non-inflammatory, is non-pyrogenic and is well tolerated. Sodium hyaluronate preparation has been shown to be non-antigenic. ORTHOVISC does not interfere with normal wound healing processes.

ORTHOVISC is indicated for the symptomatic treatment of temporomandibular joint dysfunction and osteoarthritis of the knee.

At the present time there are no known contraindications to the use of ORTHOVISC when used in the symptomatic treatment of the joint disease.

Individuals prone to chicken-or chicken-derived product allergies could, conceivably, experience an adverse reaction to sodium hyaluronate preparations. However, such reactions have not been reported previously, despite wide usage of sodium hyaluronate in the form of preparations identical to ORTHOVISC during other surgical procedures. There are minimal risks associated with the procedure of injecting substances into joints in general; primarily infection and bleeding. Pre-existing infections of skin in the region of the intended injection or known systemic bleeding disorders may constitute relative or absolute contraindications.


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